Association of TGF-β1 Polymorphism and TGF-β1 Levels With Chronic Hepatitis C and Cirrhosis: A Systematic Review and Meta-Analysis

Despite the extensive research conducted on relationship between transforming growth factor-beta 1 (TGF-β1) polymorphisms and levels onset development of liver disease, there are still certain gaps that need to be addressed. To address these provide a comprehensive overview current knowledge, this review aimed identify relevant published TGF-β1/TGF-β1 polymorphism, levels, their associations with cirrhosis hepatitis C. The synthesis available data was performed further enhance our understanding in area. Adopting Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) guidelines, search strategy implemented across several online databases articles as per defined selection criterion. Eight studies were selected after completion strategy. Of eight studies, five revealed considerably high level TGF-β1 patients who had C virus (HCV) caused by hepatocellular carcinoma (HCC). forest plot analysis showed statistically significant impact polymorphism incidence hepatic C, an odds ratio (OR) 0.65 risk (RR) 0.76. heterogeneity test at 94% 95% OR RR, respectively, but overall effect P < 0.01 both measures. According results obtained, authors concluded its associated should taken into account while developing preventive therapeutic approaches